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- Valerie Jaroenpuntaruk and Adam Gray.
- Department of Medicine, University of Kentucky College of Medicine, Lexington, KY valerie.jaroen@uky.edu.
- Cleve Clin J Med. 2023 Jun 1; 90 (6): 373381373-381.
AbstractPotentially deadly drug rashes include Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, and drug-induced vasculitis. Differentiating them can be a challenge. Factors to consider include timing of rash to drug exposure, rash distribution and clinical appearance, and the presence of systemic features such as mucosal involvement, organ failure, or eosinophilia. Various scoring systems aid in the diagnosis, but skin biopsy is the gold standard. Prompt identification and withdrawal of the suspected offending agent are the crucial first steps in management.Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved.
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