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J Clin Monit Comput · Dec 2023
Quantifying pulse oximeter accuracy during hypoxemia and severe anemia using an in vitro circulation system.
- Raymond Gylys, John Feiner, Jonas Pologe, Theodore Delianides, Stephanie Sutter, Philip Bickler, and Michael S Lipnick.
- Hypoxia Lab, Department of Anesthesia, University of California San Francisco, San Francisco, CA, USA. raymond.gylys@ucsf.edu.
- J Clin Monit Comput. 2023 Dec 1; 37 (6): 144114491441-1449.
AbstractAnemia and hypoxemia are common clinical conditions that are difficult to study and may impact pulse oximeter performance. Utilizing an in vitro circulation system, we studied performance of three pulse oximeters during hypoxemia and severe anemia. Three oximeters including one benchtop, one handheld, and one fingertip device were selected to reflect a range of cost and device types. Human blood was diluted to generate four hematocrit levels (40%, 30%, 20%, and 10%). Oxygen and nitrogen were bubbled through the blood to generate a range of oxygen saturations (O2Hb) and the blood was cycled through the in vitro circulation system. Pulse oximeter saturations (SpO2) were paired with simultaneously-measured O2Hb readings from a reference CO-oximeter. Data for each hematocrit level and each device were least-squares fit to a 2nd-order equation with quality of each curve fit evaluated using standard error of the estimate. Bias and average root mean square error were calculated after correcting for the calibration difference between human and in vitro circulation system calibration. The benchtop oximeter maintained good accuracy at all but the most extreme level of anemia. The handheld device was not as accurate as the benchtop, and inaccuracies increased at lower hematocrit levels. The fingertip device was the least accurate of the three oximeters. Pulse oximeter performance is impacted by severe anemia in vitro. The use of in vitro calibration systems may play an important role in augmenting in vivo performance studies evaluating pulse oximeter performance in challenging conditions.© 2023. The Author(s).
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