• Internal medicine journal · Jun 2023

    Case Reports

    The C3 conundrum.

    • Maria Lean and Bobby Chacko.
    • Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.
    • Intern Med J. 2023 Jun 1; 53 (6): 106510691065-1069.

    AbstractA 62-year-old man with nephritic syndrome underwent a kidney biopsy which revealed a C3 dominant pattern on immunofluorescence. A diagnosis of C3 glomerulopathy (C3G) was suspected. However, a recent skin infection and high levels of anti-streptococcal antibodies were indicative of post-infectious glomerulonephritis (PIGN). This paper compares PIGN and C3G and describes an atypical form of PIGN with alternative complement pathway dysregulation.© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.

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