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- Hirowati Ali, Tofrizal Tofrizal, Djong Hon Tjong, Amel Yanis, and Sisca Dwi Yarni.
- Department of Biochemistry, Faculty of Medicine, Andalas University, Indonesia.
- Arch Med Sci. 2023 Jan 1; 19 (3): 820824820-824.
IntroductionOur study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer's disease (AD).MethodsTwenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl3 group was given 300 mg/kg body weight (BW) of AlCl3 intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed.ResultsMSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group.ConclusionsMSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.Copyright: © 2023 Termedia & Banach.
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