• Mengyu Zhang, Jiankang Zhang, and Zengshu Xing.
• Department of Urology, Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou, 570208, China.
• Ir J Med Sci. 2024 Feb 1; 193 (1): 273327-33.

BackgroundIn recent years, triglyceride-glucose index (TyG) was a new indicator of insulin resistance, and it has been widely reported that it may be associated with serum prostate-specific antigen (PSA) concentrations.AimsWe intended to investigate the possible connection between serum PSA concentration and the TyG index.MethodsThis is a cross-sectional study of adults with complete data on TyG and serum PSA concentrations (ng/ml) from the NHANES, 2003-2010. The TyG index is obtained by the formula below: TyG = Ln [triglycerides (mg/dL) × fasting glucose(mg/dL)/2]. Multivariate regression analysis and subgroup analysis were used to examine the connection between the TyG index and serum PSA levels.ResultsMultiple regression analysis of the weighted linear model showed that individuals with a higher TyG index had lower PSA levels. Subgroup analyses and interaction tests showed no apparent dependence on age, race/ethnicity, BMI, household income ratio, education level, and marital status on this negative association (all interactions p > 0.05).ConclusionsTyG index is related to lower serum PSA concentrations in adult men from the USA. Further comprehensive prospective studies are needed to confirm our findings.© 2023. The Author(s).

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