• Mol Pain · Jan 2023

    Pain-related Behavioral and Electrophysiological Actions of Dynorphin A (1-17).

    • Justin E LaVigne, Ian M Adams, Marena A Montera, Karin N Westlund, and Sascha Ra Alles.
    • Department of Anesthesiology and Critical Care Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
    • Mol Pain. 2023 Jan 1; 19: 1744806923118659217448069231186592.

    AbstractDynorphin A (1-17) (DynA17) has been identified as a key regulator of both sensory and affective dimensions of chronic pain. Following nerve injury, increases in DynA17 have been reported in the spinal and supraspinal areas involved in chronic pain. Blocking these increases provides therapeutic benefits in preclinical chronic pain models. Although heavily characterized at the behavioral level, how DynA17 mediates its effects at the cellular physiological level has not been investigated. In this report, we begin to decipher how DynA17 mediates its direct effects on mouse dorsal root ganglion (DRG) cells and how intrathecal administration modifies a key node in the pain axis, the periaqueductal gray These findings build on the plethora of literature defining DynA17 as a critical neuropeptide in the pathophysiology of chronic pain syndromes.

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