• Nutrition · Sep 2023

    Higher serum uric acid is associated with body fat, retinol-binding protein 4, and antioxidative status in Brazilian children.

    • NovaesJuliana Farias deJFDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil. Electronic address: jnovaes@ufv.br., FilgueirasMariana De SantisMSDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil., Lara Gomes Suhett, Mariane Alves Silva, Fernanda Martins de Albuquerque, Rafaela Mara Silva Fonseca, and PeluzioMaria do Carmo GouveiaMDCGDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil..
    • Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil. Electronic address: jnovaes@ufv.br.
    • Nutrition. 2023 Sep 1; 113: 112079112079.

    ObjectiveThe aim of this study was to evaluate the association of serum uric acid (SUA) with adiposity, adipokines, and anti- and oxidative markers in Brazilian children.MethodsThis was a cross-sectional investigation with 378 children ages 8 to 9 y in Viçosa, Minas Gerais, Brazil. Information on sociodemographic and lifestyle characteristics was obtained via questionnaires, and body fat was determined by dual energy x-ray absorptiometry. We compared the distributions of adiposity (total and central), adipokines (adiponectin, chemerin, leptin, and retinol-binding protein 4 [RBP4]), anti- and oxidative markers (plasma ferric reducing antioxidant power [FRAP], superoxide dismutase [SOD], and malondialdehyde [MDA]) by SUA categories using linear regression.ResultsSUA was positively associated with total and central fat. Every standard deviation (SD) of SUA was related, respectively, to a 3.4 (95% confidence interval [CI], 2.4-4.4), 4 (95% CI, 2.8-5.1), 4.2 (95% CI, 2.9-5.5), and 3.5 (95% CI, 2.4-4.6) units higher of total, truncal, android, and gynoid fat. We found a positive association of SUA with RBP4 and FRAP, and a negative association with MDA. Every SD of SUA was related, respectively, to 0.1 (95% CI, 0.01-0.1) and 7.8 (95% CI, 5.5-10.1) units higher of RBP4 and FRAP; and to -0.3 (95% CI, -0.5 to -0.1) units lower of MDA.ConclusionsSUA was positively associated with adiposity, RBP4, and antioxidative status in Brazilian children.Copyright © 2023 Elsevier Inc. All rights reserved.

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