• Yuqun Wang, Jia He, Honglei Ma, Junhong Liu, Linping Du, Chunxiang Chai, Yajing Liu, and Xiaodong Wang.
• Department of Rheumatology and Immunology, School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, Shandong Province, China.
• Ir J Med Sci. 2024 Feb 1; 193 (1): 211221211-221.

BackgroundWith the development of sequencing technologies, there is increasing evidence that long noncoding RNAs (lncRNAs) are involved in systemic lupus erythematosus (SLE). The level of NR_103776.1 expression in SLE and its clinical associations are still not well defined.ObjectiveTo identify differentially expressed lncRNAs and explore their functional roles in SLE.MethodsTranscriptome sequencing was used to screen differentially expressed lncRNAs and mRNAs. Expression validation of clinical samples was performed by QRT-PCR. Bioinformatics was used to analyze its prognostic value and potential function.ResultsOf the 231 significantly differentially expressed lncRNAs, NR_103776.1 could be used to distinguish not only SLE patients and rheumatoid arthritis patients but also active SLE patients, stable SLE patients, and healthy controls. NR_103776.1 was significantly and negatively correlated with inflammatory indexes (CRP and ESR). NR_103776.1 dysregulation might contribute to the metabolism of RNA and proteins in SLE patients.ConclusionsThis study not only provided a transcriptome profile of lncRNAs aberrantly expressed in individual nucleated cells of SLE patients but also suggested NR_103776.1 as a novel potential diagnostic biomarker.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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