• Thomas M Gill, Ling Han, Shelli L Feder, Evelyne A Gahbauer, Linda Leo-Summers, and Robert D Becher.
• Department of Internal Medicine, Yale School of Medicine, New Haven, CT.
• Ann. Surg. 2024 Jan 1; 279 (1): 657065-70.

ObjectivesTo evaluate the relationship between distressing symptoms and changes in disability after major surgery and to determine whether this relationship differs according to the timing of surgery (nonelective vs elective), sex, multimorbidity, and socioeconomic disadvantage.BackgroundMajor surgery is a common and serious health event that has pronounced deleterious effects on both distressing symptoms and functional outcomes in older persons.MethodsFrom a cohort of 754 community-living persons, aged 70 or older, 392 admissions for major surgery were identified from 283 participants who were discharged from the hospital. The occurrence of 15 distressing symptoms and disability in 13 activities were assessed monthly for up to 6 months after major surgery.ResultsOver the 6-month follow-up period, each unit increase in the number of distressing symptoms was associated with a 6.4% increase in the number of disabilities [adjusted rate ratio (RR): 1.064; 95% CI: 1.053, 1.074]. The corresponding increases were 4.0% (adjusted RR: 1.040; 95% CI: 1.030, 1.050) and 8.3% (adjusted RR: 1.083; 95% CI: 1.066, 1.101) for nonelective and elective surgeries. Based on exposure to multiple (ie, 2 or more) distressing symptoms, the adjusted RRs (95% CI) were 1.43 (1.35, 1.50), 1.24 (1.17, 1.31), and 1.61 (1.48, 1.75) for all, nonelective, and elective surgeries. Statistically significant associations were observed for each of the other subgroups with the exception of individual-level socioeconomic disadvantage for the number of distressing symptoms.ConclusionsDistressing symptoms are independently associated with worsening disability, providing a potential target for improving functional outcomes after major surgery.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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