• Lili Deng, Yang Li, and Jincai Zhong.
• Department of Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, PR China.
• Medicine (Baltimore). 2023 Jul 7; 102 (27): e34192e34192.

RationaleMale secretory breast cancer is a rare, low-grade carcinoma, especially in boys. Due to its rarity, not much is known about this disease.Patient ConcernsA 5-year-old boy presented with a 1.4 cm painless mass in the right breast.DiagnosesUltrasonography could not distinguish whether the breast tumor was benign or malignant. After a biopsy of the lumpectomy specimen, it was diagnosed to be secretory breast carcinoma.InterventionsThe patient underwent a modified radical mastectomy for his right breast. No postoperative chemotherapy or radiotherapy was performed. Next-generation sequencing of 211 cancer-related genes was detected, and the results revealed an ETV6-NTRK3 translocation and a PDGFRB c.2632A > G mutation. None of the most commonly altered molecules in male aggressive breast cancer (such as BRCA1-2, TP53, RAD51C, and RAD51D mutations) has been identified.OutcomesThe patient was still free from local recurrence or metastases at 6-month follow-up.LessonsThe genomic profile of male pediatric SCB is relatively simple, no other known driver genes have been found except for the ETV6-NTRK3 fusion. Our report will improve our understanding of secretory breast cancer.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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