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- Muhammad Affan and Marrium S Dar.
- Department of Internal Medicine, Jinnah Sindh Medical University, Karachi, Pakistan. affanilyasintro@gmail.com.
- Ir J Med Sci. 2024 Feb 1; 193 (1): 231232231-232.
AbstractType 1 diabetes is an autoimmune disorder which is caused due to T-cell mediated destruction of β cells of pancreas leading to insulin deficiency and hyperglycemia. The prevalence has been increasing in many countries especially Europe and America. The exogenous therapy which includes insulin administration is not sufficient in maintaining the glucose levels especially in patients with brittle T1D. Therefore, endogenous production of insulin via islet cell therapy has been a center of research for many years and results have largely supported the idea. The US. FDA approved the first cell therapy drug, Donislecel for brittle T1D which may be a crucial achievement in treatment of the autoimmune disorder.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.
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