• Saudi Med J · Sep 2015

    Review

    Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension.

    • Wenchao Yang, Zhenmin Zhu, Jin Wang, Wei Ye, and Yong Ding.
    • School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China. E-mail. chaosyw@126.com.
    • Saudi Med J. 2015 Sep 1; 36 (9): 103910451039-45.

    ObjectivesTo evaluate the relationship between alpha epithelial sodium channel (alpha-ENaC) T663A polymorphism and the risk of essential hypertension. MethodsThis meta-analysis was conducted between November 2014 and February 2015 in Shanghai Medical Instrumentation College, Shanghai, China. We collected all published available case-control data (N=12) identified through PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI) up to December 2014. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed- or random-effect model. Results  Although subgroup analysis showed that alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals (OR=1.55, 95% CI=1.22-1.98, p=0.0003), our meta-analysis results did not confirm such association overall (OR=1.03, 95% CI=0.92-1.15, p=0.62). The lack of association was further confirmed by the non-superiority test (p less than 0.0001). ConclusionAlpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension.

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