• Liang Chen, Hao Peng, Bo-Lin Wang, Wen-Yuan Yu, Xiao-Hang Ding, Ming-Xin Gao, and Yang Yu.
• Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
• Medicine (Baltimore). 2023 Jul 14; 102 (28): e34247e34247.

BackgroundWe visually assessed the research hotspots of familial hypercholesterolemia (FH) using bibliometrics and knowledge mapping in light of the research state and development trend of FH.MethodsWe employed bibliometric tools, such as CiteSpace and the alluvial generator, to illustrate the scientific accomplishments on FH by extracting pertinent literature on FH from the Web of Science Core Collection database from January 1, 2002, to December 31, 2022.ResultsA total of 4402 papers in total were selected for study; 29.2% of all articles globally were from the USA, followed by the Netherlands and England. The University of Amsterdam, University of Oslo, and University of Western Australia are the 3 institutions with the most publications in this area. Gerald F. Watts, Raul D. Santos, and John J. P. Kastelein wrote the majority of the pieces that were published. The New England Journal of Medicine, Circulation, and Atherosclerosis were the journals with the greatest number of papers in this field. Prevalence and genetic analysis of FH, proprotein convertase subtilisin/kexin 9 inhibitors, and inclisiran are current research hotspots for the condition. Future research in this area will be focused on gene therapy.ConclusionsFH research has shown shows a trend of ascending followed by leveling off. The prevalence and diagnosis of FH, proprotein convertase subtilisin/kexin 9 inhibitors, inclisiran, and gene therapy are current research hotspots. This report may serve as a reference for current research trends.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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