• Xuechao Li, Sisi Zeng, Jixiang Wan, Zhen Yang, and Fangjun Wang.
• Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
• Medicine (Baltimore). 2023 Jul 14; 102 (28): e34265e34265.

AbstractThe level of endothelial glycocalyx (EG) shedding is associated with morbidity and mortality, and vascular endothelial barrier dysfunction is one of the pivotal clinical problems faced by critically ill patients, so research on the protective effects of EG is of great clinical significance for the treatment of critically ill diseases. Studies have illustrated that clinical anesthesia has different degrees of effects on vascular EG. Therefore, we reviewed the effects of distinct anesthesia methods and diverse anesthetic drugs on EG, aiming to provide a brief summary of what we know now, and to discuss possible future directions for investigations in this area. So as to provide a theoretical basis for future research on potential EG-positive drugs and targets, to minimize perioperative complications and improve the prognosis of surgical patients.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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