• Bruna Cuoco Provenzano, Thiago Prudente Bartholo, Kennedy Martins Kirk, Mario Fritsch Neves, Marcelo Ribeiro-Alves, Ana Paula Ramos Barreto, Nadja Polisseni Graça, Paulo Roberto Chauvet Coelho, Claudia Henrique da Costa, and Rogerio Rufino.
• Rio de Janeiro State University, Rio de Janeiro, Brazil.
• Medicine (Baltimore). 2023 Jul 14; 102 (28): e34073e34073.

AbstractNitric oxide (NO) is an important product of eosinophilic metabolism, and its increase is associated with bronchial remodeling and airway hyperresponsiveness. Fractional exhaled NO (FENO) in the expired air of patients with suspected or diagnosed asthma has been used as a marker for eosinophilic inflammation. This cohort study included asthmatic patients classified under steps 3, 4, or 5 of the global strategy for asthma management and prevention. In the morning of the same day, all patients underwent blood collection for eosinophil counts, followed by FENO measurement and spirometry. We considered 2 groups based on the bronchodilation (BD) response on spirometry (>10% of FVC or FEV1): positive (BD+) and negative (BD-). Differences between the 2 groups were analyzed for demographic features, FENO values, and predictive correlations between FENO and BD. Both groups of patients showed an increase in the eosinophil count (BD+, P = .03; BD-, P = .04) and FENO values (P = .015 for both) with an increase in the asthma severity from step 3 to step 5 of the global strategy for asthma management and prevention. The correlations of FENO and eosinophils as well as FENO values and BD + were 0.127 (95% confidence interval,-0.269 to -0.486) and 0.696 (95% confidence interval, 0.246-0.899; P = .007), respectively. Measuring FENO levels may be useful for identifying patients with BD+.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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