• Saud Bahaidarah, Fatma Alzahrani, Mohammed Alshinqiti, Nader Moria, Fahad Alahwal, Khalid Naghi, Ammar Abdulfattah, Mohammed Alharbi, and Gaser Abdelmohsen.
• From the Department of Pediatrics (Bahaidarah, Alzahrani, Abdelmohsen), King Abdulaziz University Hospital, from the Faculty of Medicine (Alshinqiti, Moria, Alahwal, Naghi, Abdulfattah, Alharbi) King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; and from the Department of Pediatrics (Abdelmohsen), Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.
• Saudi Med J. 2023 Jul 1; 44 (7): 655660655-660.

ObjectivesTo investigate changes in blood pressure (BP) among pediatric patients with sickle cell disease (SCD) and determine the variables that might influence these changes.MethodsA total of 100 pediatric patients with SCD who followed up in the pediatric outpatient clinic were recruited for this retrospective cohort study. Clinical data included anthropometric measures, average systolic and diastolic BP recorded during multiple follow-up visits, hemoglobin (Hb) level, serum creatinine, and hemoglobin S percentage. Blood pressure measurements were categorized according to the guidelines of the American Academy of Pediatrics (AAP, 2017).ResultsIn this cohort, 68% of the patients had normal systolic BP, 13% had elevated systolic BP, 17% had stage 1 hypertension (HTN), while only 2% reported stage 2 HTN. Patients who were overweight had relatively high systolic BP compared to patients who were underweight (p=0.034) or had normal weight (p=0.023). The average systolic BP significantly correlates with body mass index (r= 0.377, p<0.001) and serum creatinine (r=0.369, p<0.001).ConclusionPediatric overweight SCD patients exhibited higher average systolic BP than those underweight or normal weight. Body mass index and serum creatinine significantly influenced the average systolic BP more than the Hb level or Hb S percentage.Copyright: © Saudi Medical Journal.

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