• Chun Gao, Jing-Jing Jiang, Jun-Feng Mao, Xiao-Hui Yu, Xiao-Feng Zheng, and Jiu-Cong Zhang.
• Department of Gastroenterology, The 940 Hospital of Joint Logisitic Support Forces of PLA, Lanzhou, China.
• Medicine (Baltimore). 2023 Jul 21; 102 (29): e34314e34314.

BackgroundCoronavirus disease 2019 (COVID-19) was first detected in December 2019, and declared as a pandemic by the World Health Organization (WHO) on March 11, 2020. The current management of COVID-19 is based generally on supportive therapy and treatment to prevent respiratory failure.MethodsPubMed, Web of Science, Embase, CNKI, and other databases were searched by computer, and relevant literature published from December 2019 to November 2022 on the influencing factors of infection in close contacts with novel coronavirus pneumonia was collected. Meta-analysis was carried out after literature screening, quality assessment, and data extraction.ResultsA total of 425 articles were retrieved and 11 were included. Meta-analysis showed that there were 6 risk factors, and the combined OR value and 95% CI of each influencing factor were 5.23 (3.20, 8.57) for family members, 1.63 (0.56, 4.77) for regular contact, 2.14 (0.62, 7.32) for the elderly, 0.58 (0.001569.89) for cohabitation, 1.97 (1.02, 3.82) for women and 0.75 (0.01, 54.07) for others. The Deeks' funnel diagram indicates that there is no potential publication bias among the included studies.ConclusionFamily members and gender differences are the risk factors of infection among close contacts, and it cannot be proved that there are differences in infection among frequent contact, advanced age, and living together.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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