• Gonzalo Cabezón, Javier López, Isidre Vilacosta, Gilbert Habib, José María Miró, Carmen Olmos, Cristina Sarriá, Marta Hernandez-Meneses, Carlos González-Juanatey, José Ramón González-Juanatey, Jaume Llopis, Guillermo Cuervo, Carmen Sáez, Itziar Gómez, and J Alberto San Román.
• Hospital Clínico Universitario, CIBERCV, Valladolid, Spain.
• Medicine (Baltimore). 2023 Jul 21; 102 (29): e34322e34322.

AbstractThe "3 noes right-sided infective endocarditis" (3no-RSIE: no left-sided, no drug users, no cardiac devices) was first described more than a decade ago. We describe the largest series to date to characterize its clinical, microbiological, echocardiographic and prognostic profile. Eight tertiary centers with surgical facilities participated in the study. Patients with right-sided endocarditis without left sided involvement, absence of drug use history and no intracardiac electronic devices were retrospectively included in a multipurpose database. A total of 53 variables were analyzed in every patient. We performed a univariate analysis of in-hospital mortality to determine variables associated with worse prognosis. the study was comprised of 100 patients (mean age 54.1 ± 20 years, 65% male) with definite 3no-RSIE were included (selected from a total of 598 patients with RSIE of all the series, which entails a 16.7% of 3no-RSIE). Most of the episodes were community-acquired (72%), congenital cardiopathies were frequent (32% of the group of patients with previous known predisposing heart disease) and fever was the main manifestation at admission (85%). The microbiological profile was led by Staphylococci spp (52%). Vegetations were detected in 94% of the patients. Global in-hospital mortality was 19% (5.7% in patients operated and 26% in patients who received only medical treatment, P < .001). Non-community acquired infection, diabetes mellitus, right heart failure, septic shock and acute renal failure were more common in patients who died. the clinical profile of 3no-RSIE is closer to other types of RSIE than to LSIE, but mortality is higher than that reported on for other types of RSIE. Surgery may play an important role in improving outcome.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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