• Dunhuang Peng, Ting Qiu, Shaohua Chen, Weitao Hu, and Taiyong Fang.
• Department of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, P.R. China.
• Medicine (Baltimore). 2023 Jul 28; 102 (30): e34491e34491.

RationaleHeterotopic gastric mucosa (HGM) can occur in all segments of the gastrointestinal tract, but rectal is very rare. In recent years, rectal HGM is more often treated by endoscopic resection (ER).Patient ConcernsA 28-year-old female was admitted to the hospital with the chief complaint of "a rectal lesion found on physical examination".DiagnosesHeterotopic gastric mucosa (HGM).InterventionsAn endoscopic submucosal dissection (ESD) was performed to completely dissect the lesion.OutcomesThe patient recovered well at 1 month of follow-up and did not suffer from further blood in the stool.LessonsRectal HGM has acid secretion function and HP can be colonized, causing a variety of symptoms such as abdominal pain, bloody stool, and anal pain and has the potential risk of malignant transformation; resection is the best treatment method, and ESD has its unique advantages and can be promoted in the clinic.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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