• J Coll Physicians Surg Pak · Aug 2023

    Diagnostic Importance of PAX2, ARID1A, and FOXA1 Biomarkers in Atypical Endometrial Hyperplasia.

    • Ozlem Nur Yildiz, Cumhur Selcuk Topal, and Itir Ebru Zemheri.
    • Department of Pathology, SEKA State Hospital, Kocaeli, Turkiye.
    • J Coll Physicians Surg Pak. 2023 Aug 1; 33 (8): 847851847-851.

    ObjectiveTo evaluate the contribution of PAX2, ARID1A, and FOXA1 biomarkers to diagnosis in cases with atypical endometrial hyperplasia (AEH).Study DesignDescriptive Study. Place and Duration of the Study: Pathology Department of Umraniye Training and Research Hospital, from January 2018 to December 2020.MethodologyCurettage materials of 100 patients diagnosed with AEH which stained PAX2, ARID1A, and FOXA1, were evaluated. The staining patterns in the atypical endometrial glandular areas were grouped as slight-no loss, moderate loss, and complete loss / severe loss for all three biomarkers. Complete or/severe loss in AEH was considered helpful in the diagnosis.ResultsComplete loss / severe loss rates in curettages were 84% for PAX2, 5% for ARID1A, and 15% for FOXA1, respectively. When used in combination, complete loss / severe loss rates were 85% in at least one of the three markers, 84% in PAX2 and/or ARID1A, 85% in PAX2 and/or FOXA1, and 17% in ARID1A and/or FOXA1.ConclusionAlthough all 3 biomarkers showed marked staining loss, PAX2 is the most sensitive biomarker for the diagnosis of AEH in curettage materials.Key WordsEndometrium, Atypical hyperplasia, PAX2, ARID1A, FOXA1.

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