• Zhu Yanan, Wang Juan, Wang Jun, Ma Xin, Wu Kejian, and Wang Fangyu.
• From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
• Saudi Med J. 2023 Aug 1; 44 (8): 795800795-800.

ObjectivesTo study the levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199, CA724, CA242, pepsinogen (PG) I, PGII, gastrin-17 (G-17), the PGI/PGII ratio (PGR), as well as the expression of p27 and Ki67, in patients suffering from early gastric cancer and intraepithelial neoplasia and to provide new markers for the diagnosis of early gastric cancer and precancerous lesions.MethodsA retrospective study where the blood serum concentration of CEA, CA199, CA724, CA242, PGI, PGII, G-17 and PGR were tested and also the protein expression of p27 and Ki67 was detected in patients tissues by immunohistochemistry in the Gastrointestinal Endoscopy Center of the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, from March 2018 to March 2021.ResultsCarbohydrate antigen 242 and CA199 levels in tumor tissue significantly differed among the groups. Pepsinogen I levels decreased with increasing disease severity, G-17 levels increased with the aggravation of severity, and p27 expression decreased with the severity.ConclusionThe combination of serum gastric function markers (PGI and G-17) and p27 digestive tumor indices can serve as markers for the diagnosis of early gastric cancer and intraepithelial neoplasia.Copyright: © Saudi Medical Journal.

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