• Jianjun Liu, Hongwei Zhang, Xiaogang Zhang, Tao He, Xiyun Zhao, and Zhipeng Wang.
• Department of Orthopaedic, Affiliated Hospital of Gansu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2019 May 1; 98 (20): e15635e15635.

BackgroundLumbar spinal stenosis (LSS) is a common and frequently-occurring disease in clinical practice. There are many interventions to treat it, and percutaneous endoscopic decompression (PED) is one of them, but their relative efficacy and safety remains unclear. Hence, the present study aims to synthesize the available direct and indirect evidence on the PED and other treatments for LSS.MethodsThe following databases will be searched: Cochrane Library, PubMed, Web of Science, Embase and China Biomedical Literature Database (CBM). The search dates will be set from the inception to April 2019. All randomized controlled trials (RCTs) will be included in this network meta-analysis (NMA) and their risk of bias will be assessed using Cochrane handbook tool by 2 independent authors. The efficacy outcomes including: Back and Leg Visual Analog Scale (VAS) score, MacNab criteria, the Oswestry Disability Index (ODI), and Japanese Orthopedic Association (JOA) score. The safety outcomes including: incidence of complications (dura tear, incomplete decompression, reoperation, etc.). A network meta-analysis will be performed using R x64 3.5.1 software and pairwise meta-analysis will be conducted using Stata 12.0 software. Grading of recommendations assessment, development, and evaluation (GRADE) will be used to assess evidence quality.ResultsThe results of NMA will be submitted to a peer-reviewed journal.ConclusionThe NMA will provide a comprehensive evidence summary on treatments for patients with LSS.Protocol Registration NumberCRD42019120509.

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