• Yong Li, Xiaohua Zhang, Xiaoxiao Chen, Dezhu Chen, Qian Yu, Shenglan Yang, and Mingjian Lang.
• Department of Cardiology, The Fifth People's Hospital affiliated to Chengdu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Feb 1; 99 (7): e18966e18966.

BackgroundChinese herbal preparations (CHPs) have been reported to be effective in the management of chronic heart failure (CHF); they are beneficial in improving cardiac function, reducing hospital stays and readmission. However, the credibility of their effectiveness evidence has not been evaluated. We aim to summarize and evaluate current effectiveness evidence of traditional Chinese medicine in the management of CHF.MethodsWe will search PubMed, Embase, the Cochrane Database of Systemic Review (CDSR), and Web of Science from inception to December 2019 for systematic reviews that assessing the effectiveness of CHPs for CHF. The search will be performed without language restriction. Experimental interventions will include any type of CHPs, and control interventions will include placebo, sham interventions, usual care, or no controls. The primary outcome will be the changes in heart function classification defined by the New York Heart Association. Secondary outcomes include left ventricular ejection fraction, Six Minute Walk Test, other efficacy outcomes, and adverse events. We will use I statistics to assess the between-study heterogeneity in each meta-analysis, Eager test to detect publication bias, and the ratio of observed versus expected number of trials with positive findings. We will summarize the evidence and classify them into convincing, highly suggestive, suggestive, or weak.ResultsThe results of this study will be published in a peer-reviewed journal.Ethics And DisseminationNo ethical approval and patient consent are required since this study data is based on published literature. The results of the study will be submitted to a peer-reviewed journal.Protocol Registration NumberPROSPERO CRD 42019139649 (https://www.crd.york.ac.uk/PROSPERO/#joinuppage).

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