• Ahmet Cevdet Ceylan, Büşranur Çavdarlı, Gülay Güleç Ceylan, Vehap Topçu, S Betül Arslan Satılmış, Şerife Gökbulut Bektaş, Ayşe K Kalem, Bircan Kayaaslan, Fatma Eser, KalkanEmra AsfuroğluEADepartment of Internal Medicine, Ankara City Hospital., Osman İnan, İmran Hasanoğlu, Selcen Yüksel, İhsan Ateş, Seval İzdeş, Rahmet Güner, and C Nur Semerci Gündüz.
• Department of Medical Genetics, Faculty of Medicine, Ankara Yıldırım Beyazıt University.
• Tohoku J. Exp. Med. 2023 Nov 11; 261 (3): 179185179-185.

AbstractThe pandemic coronavirus disease 2019 (COVID-19) has caused a high mortality rate and poses a significant threat to the population. The disease may progress with mild symptoms or may cause the need for intensive care, depending on many factors. In this study, it was aimed to determine if there is a tendency due to genetic factors in COVID-19 patients. Ninety-four of 188 patients with mild clinical and 94 with severe clinical symptoms were included in the study. The targeted panel including coagulopathy (F2, F5), viral invasion (ACE2), and inflammation (CXCL8, IFNAR2, IFNL4, IL10, IL2, IL6, IRF7, TLR3, TLR7, TNF) related genes was performed sequenced by the next generation sequencing (NGS). The variants found were classified and univariate analyses were performed to select candidate variables for logistic model. Risk factors and variants were compared. It was revealed that the presence of 2 or more risk factors caused the disease to progress severely (p < 0.001). Heterozygous IRF7:c.1357-23dup variant had a 2.5 times higher risk for mild disease compared to severe disease. Other variants were found to be more significant in mild disease. Since polymorphic variants were not evaluated in the literature, the findings of our study could not be compared with the literature. However, as variants that may be effective in the severity of infections may differ according to ethnicity. This study has the feature of being a guide for subsequent studies to be carried out especially in Turkish population. Clinical course of the COVID-19 is likely to depend on a variety of risk factors, including age, sex, clinical status, immunology and genetic factors.

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