• Faxue Zhang, Heng Tang, Dingyuan Zhao, Shijie Zhu, Lianguo Ruan, and Wei Zhu.
• Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071, China.
• Prev Med. 2023 Oct 1; 175: 107689107689.

BackgroundPrevious investigations have predominantly concentrated on the influence of ozone (O3) on general population mortality. However, a noticeable gap exists regarding the attention directed towards susceptible demographics, specifically individuals afflicted by human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS).MethodsA dataset comprising 1467 AIDS-related fatalities from 2013 to 2020 was amassed from the Hubei Provincial Center for Disease Control and Prevention. Daily maximum 8-h average O3 levels and meteorological parameters were extracted from the ChinaHighAirPollutants dataset and the National Meteorological Science Data Center, respectively. A time-stratified case-crossover methodology was employed to scrutinize the connection between short-term exposure to O3 and AIDS-related deaths.ResultsA rise of one interquartile (IQR) in O3 concentration, lagged by 4 days, was associated with a 15% [95% confidence intervals (CIs): 2, 31] increase in AIDS-related deaths. Notably, males demonstrated heightened susceptibility to the adverse consequences of O3, marked by an odds ratio of 1.20 (95% CIs: 1.05, 1.37) at lag 4 day. Additionally, patients aged over 65 years exhibited escalated vulnerability to brief O3 exposure. Marriage status and educational attainment emerged as influential factors modifying the interplay between O3 and AIDS-related mortality.ConclusionsOur study presents novel evidence spotlighting the deleterious repercussions of O3 on mortality in the HIV/AIDS population.Copyright © 2023 Elsevier Inc. All rights reserved.

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