• Cleve Clin J Med · Sep 2023

    Review

    A practical guide for buprenorphine initiation in the primary care setting.

    • Roberto León-Barriera, Samantha Jayne Zwiebel, and Vania Modesto-Lowe.
    • Assistant Professor of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA ral187@pitt.edu.
    • Cleve Clin J Med. 2023 Sep 1; 90 (9): 557564557-564.

    AbstractBuprenorphine is a safe and effective treatment for opioid use disorder but remains underutilized because a major challenge of conventional buprenorphine initiation (termed induction) is that the patient must already be in opioid withdrawal. Previous legal barriers and clinician lack of familiarity with the unique pharmacology of buprenorphine have also limited its use. In this review, we outline changes regarding buprenorphine prescribing laws and physician perceptions of buprenorphine. We also review buprenorphine pharmacology and novel low-dose buprenorphine induction procedures that can be adopted in primary care settings to improve treatment acceptability, retention, and outcomes.Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved.

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