• Eur. J. Clin. Invest. · Jan 2024

    Association of aortic stiffness early post myocardial infarction with left ventricular remodelling.

    • George Pavlidis, Damianos Tsilivarakis, Konstantinos Katogiannis, Dimitrios Vlastos, Spyridon Katsanos, Eleni Katsanaki, John Thymis, John Parissis, Vaia Lambadiari, and Ignatios Ikonomidis.
    • 2nd Department of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    • Eur. J. Clin. Invest. 2024 Jan 1; 54 (1): e14090e14090.

    BackgroundAdverse left ventricular (LV) remodelling after myocardial infarction is associated with heart failure. We investigated whether aortic stiffness during acute ST-segment elevation myocardial infarction is associated with LV remodelling at long-term follow-up.MethodsIn 109 patients within 48 h of myocardial infarction post-primary percutaneous coronary intervention and after 2 years, we measured: (a) carotid to femoral pulse wave velocity (PWV), (b) LV global longitudinal strain (GLS) and left atrial strain using speckle-tracking echocardiography, (c) PWV/GLS ratio as a surrogate marker of ventricular-arterial interaction, and (d) LV end-diastolic and end-systolic volumes. A > 15% decrease from the baseline in LV end-systolic volume at 2-year follow-up was considered as a criterion of reverse LV remodelling.ResultsCompared with baseline, all patients had reduced PWV, LV end-diastolic and end-systolic volumes while PWV/GLS, GLS and reservoir left atrial strain were improved (p < .05) after 2 years. Baseline values of PWV, GLS, PWV/GLS ratio and reservoir left atrial strain were associated with percentage change of LV end-systolic volume at 2 years (p < .05). Multivariable analysis revealed that lower baseline values of PWV and a less impaired GLS and PWV/GLS were independently associated with reverse LV remodelling at 2 years with a C-statistic of .748, .711 and .787, respectively.ConclusionAortic stiffness early post-infarction determines LV remodelling after 2 years of the ischemic event despite post successful revascularization.Clinical Trial Registration Urlhttp://www.Clinicaltrialsgov. Unique identifier: NCT03984123, 30/04/2020.© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

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