• Pak J Med Sci · Sep 2023

    Cause of death and influencing factors of chronic renal failure on maintenance hemodialysis.

    • Xing Fan, Jing Li, Zhao-Yu Bi, Wei Liang, and Feng-Juan Wang.
    • Xing Fan Department of Nephrology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei China. Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding 071000, Hebei China.
    • Pak J Med Sci. 2023 Sep 1; 39 (5): 137813821378-1382.

    ObjectiveTo investigate the causes of death in patients with chronic renal failure (CRF) on maintenance hemodialysis and its influencing factors.MethodsThis is a retrospective study. A total of 300 patients with chronic renal failure undergoing maintenance hemodialysis who were admitted to the Affiliated Hospital of Hebei University from March 2020 to October 2022 were selected as subjects. Various information of patients were collected. In addition, 80 dead patients in this group were investigated for the cause of death, including cardiovascular and cerebrovascular diseases, infections, multi organ failure, and other causes, and the death-related conditions of cardiovascular and cerebrovascular diseases, such as triglyceridr,,total cholesterol, and in blood lipid levels were analyzed.ResultsAmong the 80 dead patients, cardiovascular and cerebrovascular diseases accounted for a higher proportion of death (66%). Univariate Logistic regression analysis showed that advanced age, plasma homocysteine, blood parathyroid hormone, hyperphosphatemia, hypertension, high volume load and left ventricular hypertrophy were risk factors for death in patients with chronic renal failure on maintenance hemodialysis. Multivariate Logistic regression analysis showed that high volume load, left ventricular hypertrophy and anemia were risk factors for death on maintenance hemodialysis. The levels of hemoglobin (HGB) and high-density lipoprotein (HDL) in patients who died of cardiovascular and cerebrovascular diseases were significantly lower than those in the non-cardio-cerebrovascular death group (P=0.00), and the levels of serum phosphorus, TG and TC were significantly higher than those in the non-cardio-cerebrovascular death group (P, P=0.00; TG, P=0.02; TC, P=0.01).ConclusionCardiovascular and cerebrovascular diseases are the leading cause of death in patients with chronic renal failure on maintenance hemodialysis. Adequate dialysis and normal hemoglobin levels are favorable protective factors.Copyright: © Pakistan Journal of Medical Sciences.

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