• Pak J Med Sci · Sep 2023

    Effect of intravenous thrombolysis combined with endovascular treatment on vascular recanalization rate and peak systolic velocity in patients with acute cerebral infarction.

    • Hui Zheng, Bo Zheng, Shu Yang, Xin Mou, Xuan Zhang, Huiying Huang, and Xiaoping Wu.
    • Hui Zheng, Department of Neurology, Chengdu First People's Hospital, Chengdu 610000, Sichuan Province, P.R. China.
    • Pak J Med Sci. 2023 Sep 1; 39 (5): 129112951291-1295.

    ObjectivesTo investigate the efficacy of intravenous thrombolysis (IVT) combined with endovascular treatment (EVT) on vascular recanalization rate and peak systolic velocity (PSV) in patients with acute cerebral infarction (ACI).MethodsA retrospective observational study was conducted from January 2019 to December 2021 in Chengdu First People's Hospital. The clinical data of 96 patients with ACI were reviewed and the patients were assigned to either the control group (IVT alone, n=54) or the observation group (IVT+EVT, n=42). The vascular recanalization rate, PSV, neurological function, modified Rankin Scale (mRS) score and major adverse cardiovascular events (MACE) were compared between groups.ResultsThe vascular recanalization rate and PSV in the observation group were higher than the control group (P<0.05). The NIHSS scores of the observation group at 24 hour, one week and one month after treatment were significantly lower than those of the control group (P<0.05). The mRS scores of the observation group were significantly lower than the control group after treatment (P<0.05), while there was no difference in the incidence of MACE between groups (P>0.05).ConclusionsIVT combined with EVT can improve the vascular recanalization rate and PSV in patients with ACI, which is worthy of promotion in clinical practice.Copyright: © Pakistan Journal of Medical Sciences.

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