• Aneela Hussain, Samreen Sarfaraz, Sabiha Anis, Quratulain Sheikh, Anum Rahim, Shameem Behram, Rabeea Shah, and Owais Khan.
• Dr. Aneela Hussain, MBBS, FCPS (Internal Medicine), FCPS (Infectious Diseases) Infectious Diseases Department, Indus Hospital & Health Network, Karachi, Pakistan.
• Pak J Med Sci. 2023 Sep 1; 39 (5): 122512311225-1231.

ObjectiveThere are many cases of post-vaccination COVID-19 globally. Also, literature on serum antibodies after vaccination is abundant. Our research focuses on breakthrough infections reported at our institution during the third wave of COVID-19.MethodsA total of 177 people recruited at the Indus Hospital Karachi between May to September 2021 with COVID-19 infection were divided into vaccinated, partially vaccinated, and unvaccinated cohorts. Furthermore, a subset of the vaccinated cohort was tested for anti-NP and anti-S antibodies.ResultsThere were 119 patients with breakthrough infection, however, 74% had mild symptoms. The antibodies against NP and S were found at a higher level in those who had a breakthrough infection in comparison to healthy vaccinated controls.ConclusionVaccination does not prevent disease but does confer some immunity causing less severe infection.Copyright: © Pakistan Journal of Medical Sciences.

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