• Emre Hoca, Esra Kaplan Arat, Onur Arat, Süleyman Ahbab, Atay Can Kula, Hüseyin Öztürk, Ece Çiftçi Öztürk, Betül Çavuşoğlu Türker, Fatih Türker, and Hayriye Esra Ataoğlu.
• University of Health Sciences Turkey, Haseki Training and Research Hospital, Internal Medicine Clinic, Sultangazi, İstanbul, Turkey. emrehoca89@gmail.com.
• Ir J Med Sci. 2024 Apr 1; 193 (2): 733739733-739.

BackgroundHypermagnesemia is one of the vital electrolyte disturbances and is associated with such chronic conditions as cardiovascular, endocrinologic, renal diseases, and malignancy.AimThis study evaluates the association between hypermagnesemia and clinical course in hospitalized patients.MethodsThis study was conducted at the University of Health Sciences Haseki Training and Research Hospital Internal Medicine Clinic. We evaluated a total of 3850 patients. 2130 patients have met the inclusion criteria were included in the study. Those who were discharged with healing were evaluated as having a good prognosis. Patients who died or were transferred to the intensive care unit (ICU) were defined as having a poor prognosis. We divided the patients' serum magnesium levels into four quartiles and examined the clinical course/conditions of the patients.ResultsOf 2130 patients, 1013 (51.9%) were female. The mean age of patients with poor prognoses (69.2 ± 14.9) was higher than those with good prognoses (59.7 ± 19.1). Hypermagnesemia (4th quartile) was detected in 61 (33.9%), and hypomagnesemia (1st quartile) was found in 42 (23.3%) patients out of 180 patients with poor clinical outcomes. It was statistically significant that hypermagnesemia was more common in patients with poor prognoses (p: 0.002). Chronic kidney disease (CKD) was diagnosed in 258 (53.3%) of 484 hypermagnesemia patients. Hypermagnesemia was found to be more common in patients with CKD, which was statistically significant (p: 0.003).ConclusionsHypermagnesemia is associated with poor prognosis independent of comorbidities. Besides hypomagnesemia, hypermagnesemia should be considered a critical electrolyte imbalance.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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