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Review Case Reports
Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.
- Neeraj Berry, Sapna Pradhan, Rajesh Sagar, and Suresh Kumar Gupta.
- Department of Psychiatry, National Pharmacovigilance Centre, All India Institute of Medical Sciences, New Delhi, India.
- Pharmacotherapy. 2003 Feb 1;23(2):255-9.
AbstractA 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium. When both drugs were discontinued, his fever and rigidity subsided and biochemical irregularities spontaneously returned to normal, without any complications. Classic neuroleptic malignant syndrome (NMS) was diagnosed. Concomitant administration of lithium with olanzapine may place patients at risk for NMS. Clinicians need to be aware of this rare but potentially fatal side effect in patients of all ages, and especially in adolescents receiving both drugs.
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