• Sarah Fatimah, Asad Mehmood, Nargis Sabir, Rehan Ahmed Khan Lodhi, and Tahir Ghafoor.
• Department of Hematology, Armed Forces Institute of Transfusion, Rawalpindi, Pakistan.
• J Coll Physicians Surg Pak. 2023 Jan 1; 33 (1): 394139-41.

AbstractTransfusion-associated graft versus host disease (TA-GvHD) is a rare complication of blood transfusion. It is a delayed transfusion reaction that usually presents from day 7 to day 14 following a transfusion. It can affect both immunocompromised as well as immunocompetent patients. In immunocompetent patients, the culprit is usually the transfusion from first-degree relatives. The recipient takes the donor cells as self while the donor takes the recipient cells as foreign and the lymphocytes in the donor blood start attacking the recipient cells leading to a cascade of catastrophic events that ultimately result in a condition called TA-GvHD. The condition is usually fatal in 90% of cases. Here, we present one such case in which the maternal blood transfused to an infant cost him his life within 12 days of transfusion. Key Words: Transfusion, Homozygous antigen, Heterozygous antigen, Graft versus host disease.

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