• Saba Zaidi, Fariha Mazhar, and Ermish Mahfooz.
• Department of Neurology, Liaquat National Hospital, Karachi, Pakistan.
• J Coll Physicians Surg Pak. 2023 Jan 1; 33 (1): 747674-76.

AbstractCentral nervous system (CNS) septic embolisation is an uncommon but life-threatening condition. Clinicians should be aware of the increased risk of this complication in immunocompromised patients such as those suffering from lupus nephritis (LN). In cases of unexplained fever or neurologic symptoms, septic embolisation should be considered in the differential diagnosis. Early recognition and prompt treatment are essential for optimal outcomes. We report a case of a 21-year female with LN who presented with a 2-week history of fever, confusion, and aphasia. Neuro-imaging showed multiple microabscesses and a left middle cerebral artery (MCA) mycotic aneurysm, consistent with septic embolisation. Blood, cerebrospinal fluid, and bronchoalveolar lavage cultures were negative. The patient was treated with a combination of antibiotics and she responded well to treatment. Key Words: Female, Lupus nephritis, Mycotic aneurysm, Brain abscess.

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