• JinXiang Shang, Chao Jiang, Junhui Cai, ZhuoLin Chen, SongTao Jin, Fei Wang, WenQing Liang, YaQing Wang, SongOu Zhang, and Xujun Hu.
• Orthopedics, Affiliated Hospital of Shaoxing University, Shaoxing City, China.
• World Neurosurg. 2023 Dec 1; 180: e183e197e183-e197.

BackgroundSpinal cord injury (SCI) is a devastating condition, often leading to significant disability and impairment. As crucial immune cells, macrophages play a critical role in the pathophysiology of SCI. Understanding the current state of knowledge and research trends related to macrophages in SCI is crucial for developing effective therapeutic interventions.MethodsUsing search strategies, we retrieved relevant articles from the Web of Science Core Collection (WOSCC), resulting in a robust dataset for analysis. VOSviewer, Citespace, and PRISM were employed for analysis and visualization. Various bibliometric indicators, including publication trends, citation analysis, co-authorship networks, and keyword analysis, were utilized to assess the scholarly landscape of macrophage research in SCI.ResultsOur findings revealed a steady increase in publications over the past 33 years, indicating a growing interest in this field. We identified Popovich Phillip G was the most influential author, Ohio State University was the most influential institution, and identification of 2 distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord was the most influential paper in this field.ConclusionsThis bibliometric analysis provides a comprehensive overview of the current knowledge landscape and research trends regarding macrophages in SCI. Neuroinflammation and macrophage polarization, transplation and molecular mechanism were emerging research areas and novel directions. Our study serves as a valuable resource for researchers in spinal cord injury research and therapeutic development.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

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