• Yi Xia, Yan Liang, Shi Guo, Jie-Gen Yu, Meng-Sha Tang, Peng-Hui Xu, Fen-Dui Qin, and Guo-Pin Wang.
• Department of Humanities and management, Wannan Medical College, Wuhu, China.
• Postgrad Med J. 2018 Sep 1; 94 (1115): 508516508-516.

Purpose Of The StudyThe aim of this study was to perform a meta-analysis to derive precise estimation of the association of interleukin-23 receptor (IL-23R), IL-1 receptor 2 (IL-1R2), IL-12 beta (IL-12B), IL-10 and tumour necrosis factor (TNF)-α polymorphisms with ankylosing spondylitis (AS) susceptibility.Study DesignA systematic literature search was conducted to identify the relevant studies. Pooled OR with 95% CI was calculated to assess the strength of the association in a fixed or random-effects model.ResultsA total of 13 917 cases and 19 849 controls in 43 eligible studies were included in the meta-analysis. Seventeen single-nucleotide polymorphisms (SNPs) in the abovementioned five cytokine genes were evaluated. The results indicate that the nine SNPs (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs11209032, rs1495965, rs7517847, rs2201841) of IL-23R are associated with AS susceptibility in all study subjects in the allelic model. Moreover, stratification by ethnicity identified a significant association between seven SNPs of IL-23R and AS susceptibility in Europeans and Americans, but not in Asians. In addition, the IL-10-819  C/T and TNF-α-857 C/T polymorphisms also confer susceptibility to AS, especially in Asian population.ConclusionThe results suggested that the genetic susceptibility for AS is associated with the nine SNPs of IL-23R in overall population. In the subgroup analysis, significant associations were shown in European and American population, but not in Asian population. Our results also suggest that IL-10-819  C/T and TNF-α-857 C/T polymorphism might be associated with AS risk, especially in Asian population.© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.

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