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Randomized Controlled Trial
Is low-dose naltrexone effective in chronic pain management?
- Roxanne Radi, Harriet Huang, Jason Rivera, Corey Lyon, and Kristen DeSanto.
- University of Colorado Family Medicine Residency, Denver.
- J Fam Pract. 2023 Sep 1; 72 (7): 320321320-321.
AbstractYES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).
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