• Arch Med Sci · Jan 2023

    Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies.

    • Paweł Krzemień, Sławomir Kasperczyk, Maciej Banach, Aleksandra Kasperczyk, Michał Dobrakowski, Tomasz Tomasik, Adam Windak, Mirosław Mastej, Alberico Catapano, Kausik K Ray, Dimitri P Mikhailidis, Peter P Toth, George Howard, LipGregory Y HGYHLiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool L14 3PE, United Kingdom.Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Maciej Tomaszewski, Fadi J Charchar, Naveed Sattar, Bryan Williams, Thomas M MacDonald, Peter E Penson, and Jacek J Jóźwiak.
    • Euroimmun Polska Sp. z o.o., Wroclaw, Poland.
    • Arch Med Sci. 2023 Jan 1; 19 (5): 121412271214-1227.

    IntroductionOxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as "neo-antigens" and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA.Material And MethodsWe examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid (UA) concentration, were also measured and the oxidative stress index (OSI-index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA).ResultsThe presence of ANA in women was associated with lower physical activity (p = 0.036), less frequent smoking (p = 0.007) and drinking of alcohol (p = 0.024) accompanied by significant changes in SOD isoenzymes activity (p < 0.001) and a higher uric acid (UA) concentration (p < 0.001). In ANA positive males we observed lower concentrations of PSH (p = 0.046) and increased concentrations of MDA (p = 0.047).ConclusionsThe results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.Copyright: © 2021 Termedia & Banach.

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