• Arch Med Sci · Jan 2023

    Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance.

    • Yunfu Lv, Yejuan Li, XiaoYu Han, Ning Liu, and Min Zeng.
    • Department of General Surgery, Hainan General Hospital (Hainan Medical College Affiliated People's Hospital), Haikou, China.
    • Arch Med Sci. 2023 Jan 1; 19 (5): 156915751569-1575.

    IntroductionTo investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7.MethodsThe liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR.ResultsThe area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01).ConclusionsCXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.Copyright: © 2023 Termedia & Banach.

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