• Arch Med Sci · Jan 2023

    Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people.

    • Luyue Qi, Zhenlin Zhang, and Weiwei Hu.
    • Shanghai Clinical Research Center of Bone Diseases, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    • Arch Med Sci. 2023 Jan 1; 19 (5): 154115441541-1544.

    IntroductionThis study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population.MethodsHealthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured.ResultsThe rs141206415 in the RASAL1 gene and rs144493374 in the PALLD gene were associated with trunk FM, and the rs4807023 in the PTPRS gene was associated with leg FM using Spearman correlation analysis.ConclusionsThe results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism.Copyright: © 2023 Termedia & Banach.

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