• Sergio Valdés, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Eva García-Escobar, Sara García-Serrano, Wasima Oualla-Bachiri, Marta García-Vivanco, Juan Luis Garrido, Victoria Gil, Fernando Martín-Llorente, Alfonso Calle-Pascual, Luis Castaño, Elías Delgado, Edelmiro Menéndez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, F Javier Chaves, José L Galán-García, Gabriel Aguilera-Venegas, Joan Carles Vallvé, Núria Amigó, Montse Guardiola, Josep Ribalta, and Gemma Rojo-Martínez.
• Department of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga/Universidad de Málaga, Instituto de Investigación Biomedica de Málaga-IBIMA, Málaga, Spain.
• Eur. J. Clin. Invest. 2024 Feb 1; 54 (2): e14101e14101.

Background And AimsWe aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain.MethodsWe included 4647 adults (>18 years), participants in the national, cross-sectional, population-based di@bet.es study, conducted in 2008-2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced 1 H-NMR lipoprotein test (Liposcale®). Participants were assigned air pollution concentrations for particulate matter <10 μm (PM10 ), <2.5 μm (PM2.5 ) and nitrogen dioxide (NO2 ), corresponding to the health examination year, obtained by modelling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model).ResultsIn multivariate linear regression models, each IQR increase in PM10 , PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL-c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL-p) concentrations (p < .001 for all associations). In multivariate logistic regression, there was a significant association between PM10 , PM2.5 and NO2 concentrations and the odds of presenting low HDL-c (<40 mg/dL), low HDL-p (ConclusionsOur study shows an association between the exposure to air pollutants and blood lipids in the general population of Spain, suggesting a link to atherosclerosis.© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

25 keywords...

hide…