• Presse Med · Mar 2023

    Clinical Trials with reno-vascular end points in patients with diabetes: Changing the scenario over the past 20 years.

    • Tomasz J Block and Mark E Cooper.
    • Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.
    • Presse Med. 2023 Mar 1; 52 (1): 104178104178.

    AbstractMajor clinical advances over the last 20 years in the area of diabetic kidney disease (DKD) have been confirmed in large seminal clinical trials. These findings add to the previously identified benefits resulting from intensive glucose and blood pressure control therapies. Furthermore, newer glucose lowering treatments such as SGLT2 inhibitors and GLP-1 agonists appear very promising and are likely to transform the management and outlook of DKD over the next decade. In addition, novel mineralocorticoid receptor antagonists and a recently reported trial with an endothelin receptor blocker also have the potential to change clinical practice.Crown Copyright © 2023. Published by Elsevier Masson SAS. All rights reserved.

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