• Pierre-Jean Saulnier and Petter Bjornstad.
• Clinical Investigation Center INSERM CIC1402 CHU Poitiers, Poitiers University, School of Medicine, Poitiers, France, and NIDDK, Phoenix, AZ, USA. Electronic address: pierre.jean.saulnier@univ-poitiers.fr.
• Presse Med. 2023 Mar 1; 52 (1): 104175104175.

AbstractThe dysfunction of the internal mechanics within the kidney's filtering units, known as glomeruli, has been linked to the emergence and progression of diabetic kidney disease (DKD). To better understand this crucial aspect of kidney function and the pathology of DKD, a variety of methods are employed in research, from the introduction of external compounds, such as inulin, iohexol, iothalamate and p-aminohippurate, to cutting-edge imaging techniques and computational analysis. Given the significance of intraglomerular hemodynamic dysfunction in the pathogenesis and treatment of DKD, it is essential to thoroughly examine the available data on this topic. Accordingly, the aim of this review is to provide a comprehensive appraisal of the role of intraglomerular hemodynamic dysfunction in the development of DKD and the effects of current therapies used to mitigate DKD. Through this analysis, we can gain a deeper understanding of the complex pathogenesis of DKD and potentially discover new avenues for tailored therapeutic management of patients with DKD.Copyright © 2023 Elsevier Masson SAS. All rights reserved.

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