• Yi Gao, Diancai He, Wenqi Feng, Jing Yue, and Zhiyuan Jian.
• General Surgery I Department, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Province, China.
• Medicine (Baltimore). 2023 Oct 6; 102 (40): e35429e35429.

RationaleAn overdistended gallbladder is usually observed in cases of distal bile obstruction due to malignancy. The gallbladder may also become enlarged and distended during cystic duct or gallbladder neck obstruction due to gallstones. However, a grossly distended gallbladder ( > 14 cm in length) without any pathology is rare. We present the case of a 46-year-old female patient who suffered from acute right lower quadrant pain for 4 days. Initially, a liver cyst and a choledochal cyst were diagnosed by the local hospital. Then, the diagnosis of giant gallbladder (measuring approximately 20.0 cm × 7.0 cm and containing more than 30 gallbladder stones) was made by magnetic resonance cholangiopancreatography at our hospital. Finally, we successfully performed a laparoscopic cholecystectomy and the patient had an uneventful recovery.Patient ConcernsA 46-year-old female patient presented with acute right lower quadrant pain lasting 4 days. At first, the abdominal pain was severe and paroxysmal, and then it subsided spontaneously. Computed tomography of the abdomen at another hospital revealed a hepatic cyst and a choledochal cyst. Come to our hospital for surgical treatment.Diagnosesgiant gallbladder with gallstones.InterventionsLaparoscopic cholecystectomy was successfully performed in this patient after decompressing the gallbladder.OutcomesOn the third postoperative day, the patient recovered well, and the abdominal pain resolved following the operation. At the 3-year postoperative follow-up, the patient was symptom-free, with no obvious abnormalities seen in liver function and hepatobiliary color Doppler ultrasound.LessonsThe patient was successfully treated using laparoscopic cholecystectomy. This rare case may contribute to the development of mechanisms for treating giant gallbladders.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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