• Suwei Lan, Zhengmao Zhang, and Qing Li.
• Hebei Medical University, Hebei, China.
• Medicine (Baltimore). 2023 Oct 6; 102 (40): e35406e35406.

BackgroundEndometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown.MethodsIn this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (n = 39) and control patients without endometriosis (n = 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7.ResultsThese findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis.ConclusionFZD7 may serve as a potential therapeutic target for endometriosis treatment.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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