• Medicine · Nov 2018

    Effect of Endostar combined with chemotherapy in advanced well-differentiated pancreatic neuroendocrine tumors.

    • Yue-Juan Cheng, Chang-Ting Meng, Hong-Yan Ying, Jian-Feng Zhou, Xiao-Yan Yan, Xin Gao, Na Zhou, and Chun-Mei Bai.
    • Department of Medical Oncology, Peking Union Medical College Hospital.
    • Medicine (Baltimore). 2018 Nov 1; 97 (45): e12750e12750.

    AbstractThe aim of the present study was to assess the effect of Endostar and temozolomide or dacarbazine plus 5-fluorouracil (5-FU) in patients with advanced pancreatic neuroendocrine tumors (pNETs).Phase II study of 14 patients with locally advanced or metastatic well-differentiated pNETs treated between April 2013 and September 2016. Patients received temozolomide or dacarbazine plus 5-FU, and Endostar. The primary outcome was the radiographic response rate.All 14 patients had nonfunctional pNETs. Six patients received temozolomide and 8 received dacarbazine + 5-FU, combined with Endostar. Thirteen patients were assessable for treatment response: 1(7%) with complete response, 5 (39%) with partial response, 5 (39%) with stable disease, and 2 (15%) with progression. The median progression-free survival was 12 months. The most common grade 1/2 toxicities were neutropenia (43%) and leucopenia (21%).Endostar combined with temozolomide or dacarbazine + 5-FU was effective in the treatment of advanced pNETs. The combinations were well tolerated.

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