• Eur. J. Clin. Invest. · Feb 2024

    Anthropometric measures, predicted visceral adipose tissue and biomarkers of chronic inflammation.

    • Seán R Millar, Ivan J Perry, and Catherine M Phillips.
    • HRB Centre for Health and Diet Research, School of Public Health, University College Cork, Cork, Ireland.
    • Eur. J. Clin. Invest. 2024 Feb 1; 54 (2): e14104e14104.

    BackgroundEvidence has linked low-grade systemic inflammation and visceral adipose tissue (VAT) with development of chronic conditions. Cytokines and select proteins released by VAT may promote a low-grade inflammatory response. A number of equations have been developed to estimate VAT levels. In this study, we compared predicted VAT equation relationships with biomarkers of inflammation.MethodsThis was a cross-sectional study of 2038 men and women aged 46-73 years. Correlation and linear regression analyses were performed to examine inflammatory biomarker relationships with four commonly assessed anthropometric measures and 10 predicted VAT equations.ResultsCompared with anthropometric measures, predicted VAT equations were found to explain a greater proportion of variance in CRP (R2  = .075, p = .001), IL-6 (R2  = .060, p = .001), TNF-α (R2  = .017, p = .005), resistin (R2  = .011, p = .012), monocyte (R2  = .027, p = .001), eosinophil (R2  = .012, p = .01) and basophil (R2  = .015, p = .002) levels in males, and a greater variance in concentrations of C3 (R2  = .175, p = .001), IL-6 (R2  = .090, p = .001), TNF-α (R2  = .036, p = .001), adiponectin (R2  = .121, p = .001), the adiponectin-to-leptin ratio (R2  = .444, p = .001), resistin (R2  = .025, p = .001), white blood cell count (R2  = .057, p = .001), neutrophils (R2  = .061, p = .001) and lymphocytes (R2  = .020, p = .001) in females.ConclusionEquations for assessing VAT levels might be useful to characterise metabolic health. Further studies that examine predicted VAT relationships with disease and mortality outcomes are warranted.© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…