• Mohammad Ali Abouei Mehrizi, Mohammad Amin Habibi, Ehsan Keykhosravi, Seyed Mohammad Eazi, Poriya Minaee, and Mohammad Sina Mirjani.
• Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
• World Neurosurg. 2023 Dec 1; 180: 213223.e7213-223.e7.

BackgroundWide-necked bifurcation aneurysms (WNBAs) are challenging intracranial aneurysms. Several device and treatment approaches have been proposed for the treatment of WNBAs. The endovascular clip system (eCLIPs) is a newly developed endovascular device with flow diverter and flow disruptor features. This study aims to investigate the safety and efficacy of the eCLIPs for treatment of patients with WNBAs.MethodsThis is a systematic review and meta-analysis study conducted in accordance with the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines. The electronic databases of PubMed, Embase, Scopus, and Web of Science were systematically reviewed from inception to June 19, 2023. The rate of complete and near-complete occlusion, successful device implantation, and serious adverse events were pooled using STATA, version 17.ResultsA total of 5 studies with 110 patients with WNBAs were systematically investigated. Our findings show that the immediate successful implantation rate of eCLIPs was 0.93 (95% confidence interval [CI], 0.88-0.97). Moreover, the immediate postoperative complete occlusion rate was 0.34 (95% CI, 0.10-0.58), and the immediate postoperative near-complete occlusion rate was 0.35 (95% CI, 0.24-0.45). Also, the near-complete occlusion rate at the latest follow-up was 0.3 (95% CI, 0.16-0.44). The serious adverse event rate was 0.14 (95% CI, 0.05-0.22). Stroke was also reported in 2 studies, with 1 study reporting 1 patient who experienced stroke within the first 24 hours and 1 study reporting no patients with stroke.ConclusionsOur findings document that the eCLIPs is a safe and effective device for treating patients with WNBAs and associated with favorable outcomes.Copyright © 2023 Elsevier Inc. All rights reserved.

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