• Edoardo Mocini, Lorenzo Maria Donini, Andrea M Isidori, and Marianna Minnetti.
• Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
• Nutrition. 2024 Jan 1; 117: 112232112232.

ObjectivesVulvodynia is an emerging health problem, still insufficiently studied, that causes a significant reduction in quality of life in many women and individuals assigned female sex at birth. Little is known about the effects of diet and metabolic disorders on this condition. The objective of this study was to review currently available evidence on the diet and the nutritional and metabolic status of patients affected by vulvodynia.MethodsPublished articles were systematically searched in the PubMed, Scopus, and Web of Science databases.ResultsThe few available studies that reported data on patients' body mass index (BMI) described a BMI within the normal range in most patients affected by vulvodynia, showing no difference or a slightly lower BMI with respect to control individuals. Data on the relationship between metabolic diseases and vulvodynia are lacking. Regarding nutrition, the few available data do not support the prescription of a low-oxalate diet in women with vulvodynia. To date, studies on other dietary behaviors are also lacking.ConclusionsThis review emphasizes-for the first time, to our knowledge-the lack of data and the importance of conducting prospective studies investigating the nutritional and metabolic aspects related to the onset, maintenance, and therapy of vulvodynia.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

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