• Seyyed Mostafa Arabi, Hossein Bahari, Mahla Chambari, Leila Sadat Bahrami, Mohammaed Ibrahim Mohaildeen Gubari, Gerald F Watts, and Amirhossein Sahebkar.
• Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
• Eur. J. Clin. Invest. 2024 Feb 1; 54 (2): e14109e14109.

IntroductionN-3 polyunsaturated fatty acids (PUFAs) supplementation has been reported to have an impact on flow-mediated dilatation (FMD), a conventionally used clinical technique for estimating endothelial dysfunction. However, its proven effects on endothelial function are unclear. This systematic review and meta-analysis were conducted to evaluate the effects of n-3 PUFAs supplementation on FMD of the brachial artery.MethodThis study was performed following the PRISMA guidelines. To identify eligible RCTs, a systematic search was completed in PubMed/Medline, Scopus and Web of Science using relevant keywords. A fixed- or random-effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI).ResultsThirty-two studies (with 35 arms) were included in this meta-analysis, involving 2385 subjects with intervention duration ranging from 4 to 48 weeks. The pooled meta-analysis demonstrated a significant effect of omega-3 on FMD (WMD = 0.8%, 95% CI = 0.3-1.3, p = .001) and heterogeneity was significant (I2  = 82.5%, p < .001).ConclusionWe found that n-3 PUFA supplementation improves endothelial function as estimated by flow-mediated dilatation of the brachial artery.© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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